Glial cell line-derived neurotrophic factor-induced signaling in Schwann cells
نویسندگان
چکیده
منابع مشابه
The Effects of Progesterone on Glial Cell Line-derived Neurotrophic Factor Secretion from C6 Glioma Cells
Objective(s)Progesterone is a steroid hormone whose biology has been greatly studied within the confines of reproductive function. In recent years, the neuroprotective effects of progesterone have attracted growing interest. Glial cell line-derived neurotrophic factor (GDNF), is a neurotrophic factor which plays a crucial role in the development and maintenance of distinct sets of central and p...
متن کاملAlginate-matrigel microencapsulated schwann cells for inducible secretion of glial cell line derived neurotrophic factor.
Controlled expression of glial cell line derived neurotrophic factor (Gdnf) can be integrated in the development of a system for repair of injured peripheral nerves. This delivery strategy was demonstrated via inducible Gdnf from microencapsulated cells in barium alginate. The Schwann cell line RT4-D6P2T was initially modified utilizing an ecdysone-based stable transfection system to produce RT...
متن کاملCharacterizing The Controlled Release Of Glial Cell-Line Derived (gdnf) Neurotrophic Factor From Encapsulated Schwann Cells
CHARACTERIZING THE CONTROLLED RELEASE OF GLIAL CELL-LINEDERIVED (GDNF) NEUROTROPHIC FACTOR FROM ENCAPSULATEDSCHWANN CELLS
متن کاملthe effects of progesterone on glial cell line-derived neurotrophic factor secretion from c6 glioma cells
objective(s)progesterone is a steroid hormone whose biology has been greatly studied within the confines of reproductive function. in recent years, the neuroprotective effects of progesterone have attracted growing interest. glial cell line-derived neurotrophic factor (gdnf), is a neurotrophic factor which plays a crucial role in the development and maintenance of distinct sets of central and p...
متن کاملRet-dependent and -independent mechanisms of glial cell line-derived neurotrophic factor signaling in neuronal cells.
Glial cell line-derived neurotrophic factor (GDNF) has been shown to signal through a multicomponent receptor complex consisting of the Ret receptor tyrosine kinase and a member of the GFRalpha family of glycosylphosphatidylinositol-anchored receptors. In the current model of GDNF signaling, Ret delivers the intracellular signal but cannot bind ligand on its own, while GFRalphas bind ligand but...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2005
ISSN: 0022-3042,1471-4159
DOI: 10.1111/j.1471-4159.2005.03290.x